DRUG DEVELOPMENT DECONSTRUCTOR MANIFESTO: : “Tell me how you read and I'll tell you who you are.” ― Martin Heidegger
Thursday, December 31, 2015
Tuesday, December 29, 2015
Sunday, December 27, 2015
Saturday, December 26, 2015
Thursday, December 24, 2015
Wednesday, December 23, 2015
Sunday, December 20, 2015
Чапаев и Пустота
Публика была самая разношерстная, но больше всего было, как это обычно случается в истории человечества, свинорылых спекулянтов и дорого одетых блядей.
Saturday, December 19, 2015
Friday, December 18, 2015
Wednesday, December 16, 2015
Tuesday, December 15, 2015
Saturday, December 12, 2015
Sunday, December 6, 2015
Saturday, December 5, 2015
Friday, November 27, 2015
Tuesday, November 24, 2015
Who cares?
Pfizer is the largest drug maker in the United States, but after striking a deal on Monday to buy Allergan, the company is on the verge of becoming Irish.For shareholders, this may be their lucky charm. After the merger, Pfizer will be able to shift its legal headquarters from New York to Dublin and pay lower taxes, which should bolster its bottom line. But in the process, scientists are likely to lose their jobs, innovation may suffer, and consumers could pay more for Pfizer medicines.
This is often true of many large takeovers in the pharmaceutical industry as companies look to slash expenses and quickly appease investors. In this case, about $2 billion in cuts are planned. But the type of deal Pfizer is pursuing, which is known as a tax inversion, appears destined to accentuate the downsides
http://www.statnews.com/pharmalot/2015/11/23/pharmalot-pfizer-allergan-innovation/
Sunday, November 22, 2015
Sunday, November 15, 2015
Tuesday, November 10, 2015
Monday, November 9, 2015
Wednesday, November 4, 2015
Sunday, November 1, 2015
The top 10 biopharma pipeline disasters of 2015...
Targeted failures - most Epic ones...
http://www.fiercebiotech.com/special-reports/top-10-biopharma-pipeline-disasters-2015
http://www.fiercebiotech.com/special-reports/top-10-biopharma-pipeline-disasters-2015
The story...
When FDA inspectors showed up at a Chinese company that supplies key ingredients to two of the U.S.’s biggest drug companies, a curious thing happened.
After lunch, they walked into a quality control lab on the second floor, where they saw a worker pull what looked like a memory stick from a computer and put it in the pocket of his lab coat. The inspectors asked to see what he’d taken.
And then the man turned and ran.
http://www.bloomberg.com/news/articles/2015-10-28/fda-shows-up-a-man-runs-and-questions-emerge-on-china-s-drugs
Wednesday, October 28, 2015
Monday, October 26, 2015
Sunday, October 25, 2015
The Liberation of Gajendra
Saturday, October 24, 2015
Targeted failure of the week. Kadcyla. When rocket science medicine fails...
Oct 22 (Reuters) - ImmunoGen Inc said the gastric cancer drug it is developing with Roche Holding AG did not meet the main goal in a large study. http://finance.yahoo.com/news/immunogen-roche-gastric-cancer-drug-121659032.html
Trastuzumab emtansine ( ado-trastuzumab emtansine, trade name Kadcyla) is an antibody-drug conjugate consisting of the monoclonal antibody trastuzumab (Herceptin) linked to the cytotoxic agent DM1.
This drug is a real rocket science approach. And it failed...
Trastuzumab emtansine ( ado-trastuzumab emtansine, trade name Kadcyla) is an antibody-drug conjugate consisting of the monoclonal antibody trastuzumab (Herceptin) linked to the cytotoxic agent DM1.
Thursday, October 22, 2015
Monday, October 19, 2015
Sunday, October 18, 2015
Saturday, October 10, 2015
Thursday, October 1, 2015
Sunday, September 27, 2015
Saturday, September 26, 2015
Communist are back!
U.S. Democratic presidential candidate Hillary Clinton proposed on Tuesday a $250 monthly cap on out-of-pocket prescription drug costs and other measures to stop what she called "price gouging" by pharmaceutical companies.
At a campaign stop in Iowa, Clinton rolled out a plan to encourage the development and use of generic drugs and to end pharmaceutical companies' ability to write off consumer-directed advertising as a business expense.
Under Clinton's plan, the monthly cap would limit what insurance companies could ask patients to pay for drugs that treat chronic or serious medical conditions.
http://in.reuters.com/article/2015/09/23/us-usa-election-clinton-idINKCN0RM08D20150923
At a campaign stop in Iowa, Clinton rolled out a plan to encourage the development and use of generic drugs and to end pharmaceutical companies' ability to write off consumer-directed advertising as a business expense.
Under Clinton's plan, the monthly cap would limit what insurance companies could ask patients to pay for drugs that treat chronic or serious medical conditions.
http://in.reuters.com/article/2015/09/23/us-usa-election-clinton-idINKCN0RM08D20150923
Really small and early-stage?
By replacing a single hydrogen atom with deuterium in a 3-year-old cystic fibrosis drug developed by Vertex Pharmaceuticals, Lexington-based Concert Pharmaceuticals says it was able to show the altered version works better in a small, early-stage clinical trial.http://www.bizjournals.com/boston/blog/bioflash/2015/09/concert-shares-soar-as-it-bests-vertex-cystic.html?ana=Yahoo
Wednesday, September 23, 2015
Sunday, September 20, 2015
Saturday, September 19, 2015
Friday, September 18, 2015
Wednesday, September 16, 2015
Tuesday, September 15, 2015
Saturday, September 5, 2015
Thursday, September 3, 2015
Молитва за врагов святителя Николая Сербского:Благослови врагов моих, Господи. И я их благословляю, а не кляну. Враги мои более толкнули меня в объятия к Тебе, чем друзья. Друзья привязывали меня к земле, а враги отрывали меня от земли и разбивали всю мою надежду на землю.
Благослови врагов моих, Господи. И я их благословляю, а не кляну. Они за меня исповедовали грех мой перед миром. Они хлестали меня, когда сам я бежал от мучений. Они охаивали меня тогда, как сам я льстил себе. Они плевали в меня тогда, когда я гордился собой.
Благослови врагов моих, Господи. И я их благословляю, а не кляну. Когда я строил из себя мудреца, они звали меня безумным. Когда хотел я казаться сильным, потешались надо мной, как над карликом. Когда я хотел водительствовать людьми, они толкали меня в конец колонны. Когда намеревался мирно спать, будили меня. Враги научили меня знать, что редко кто знает: что нет у человека в мире врагов, кроме него самого.
Лишь тот ненавидит врагов, кто не знает, что враги - не враги, но суровые друзья его.
За то благослови, Господи, и друзей, и врагов моих!
Wednesday, September 2, 2015
Tuesday, September 1, 2015
Saturday, August 29, 2015
How much are you worth?
Generally, economists suggest that one additional year in perfect health in the U.S. is worth somewhere between $50,000 and $200,000 a year. http://www.washingtonpost.com/news/wonkblog/wp/2015/08/27/cancer-drugs-arent-just-really-expensive-theyre-a-bad-value/
In other Words: $4,200 and $16,700 per month
Or $137 and $548 per day....
Thursday, August 27, 2015
Friday, August 21, 2015
Sunday, August 16, 2015
What is wrong with Eli Lilly???
Eli Lilly is staking its future on a pair of high-stakes Phase III programs, shying away from any big biotech buyouts as sticker prices continue to soar.
http://www.fiercebiotech.com/story/lillys-ceo-keeps-faith-pipeline-biotech-gets-too-expensive/2015-08-14?utm_medium=rss&utm_source=feedly&utm_campaign=rss
