From here:
Cancer drugmaker Astex Pharmaceuticals Inc said it would discontinue the development of its experimental small-cell lung cancer drug, Amuvatinib, as the drug failed to achieve a high enough response rate in patients in a mid-stage study.
And amuvatinib is of course targeted compound: Amuvatinib is a small molecule multi-targeted tyrosine kinase inhibitor designed to inhibit mutant c-KIT and PDGFalpha, and disrupt DNA repair through what is likely to be a Rad51-based mechanism.
What targeted medicine will fail next?
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