Wednesday, October 3, 2012

Successful clinical trials? Very simple!



Methods Used by Pharmaceutical Companies to Get the Results They Want from Clinical Trials

 Conduct a trial of your drug against a treatment known to be inferior.

 Trial your drugs against too low a dose of a competitor drug.

 Conduct a trial of your drug against too high a dose of a competitor drug (making your drug seem less toxic).

 Conduct trials that are too small to show differences from competitor drugs.

 Use multiple endpoints in the trial and select for publication only those that give favourable results.

 Do multi-centre trials and select for publication only those results from centres that are favourable.

 Conduct subgroup analyses and select for publication only those that are favourable.

 Present results that are most likely to impress for example, reduction in relative rather than absolute risk.

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