Wednesday, March 13, 2013

Targeted failure of the week. Post No 56. Quizartinib

 
The molecule is too long? Or too complicated? In any way something went wrong with the molecule!
 
Eyebrows have been raised after Astellas Pharma decided to end its collaboration with Ambit Biosciences Corp to develop the latter's acute myeloid leukaemia treatment quizartinib.
Back in 2009, the companies entered into a collaboration focusing on FMS-like tyrosine kinase-3 (FLT-3) inhibitors, including quizartinib. Now, the Japanese drugmaker has exercised its right to terminate the agreement, citing "strategic reasons", effective September 3, 2013.

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