Quote of the day. Who is Mr Pu? The masterpice of the Master of the language!

«Путина раньше не было. Его клонировали, как овцу Долли. Взяли пункцию из печени Ельцина. Ввели в поджелудочную железу Березовского. Поставили колбочку в кафельный бокс под сияющий экран ОРТ. Залили волшебным раствором, чей рецепт удалось узнать от тещи Глеба Павловского. Раствор состоит из щепотки гексогена, волоска ваххабита, шляпы Боярского, пуантов Васильева, перхоти Райкина, пота Карелина, слюны Аяцкова, наручников Гурова, тувинского бубна и ночной туфли Собчака, добытой методами внешней разведки. Колбу с раствором, как чайник, накрыли оренбургским платком Зыкиной. Ворожба Чубайса и пение Кобзона привели к постепенному закипанию раствора. Как из белой пены Ионического моря родилась розовая прекрасная Афродита, так из булькающего, пузырящегося раствора родился Путин. Еще не полноценная взрослая особь, а малек, прозрачный, с растопыренными пальчиками, выпученными глазками, голеньким нежным хвостиком. Предстоит еще много серьезных, посильных лишь Мамуту и Абрамовичу манипуляций, прежде чем малек разовьется, утратит прозрачность, покроется бронированной кожей, обрастет железными мускулами, и мы увидим полноценного крокодила.

Но теперь, покуда зародыш весело резвится в аквариуме, мы читаем его предвыборную доктрину, написанную Сатаровым, опубликованную в «Независимой газете» Бориса Абрамыча…

Этот пошлый лепет школы Гайдара, изложенный пресным языком Юшенкова, — есть интеллектуальный пустоцвет, сравнимый по легковесности разве что с «Сибирским цирюльником», этим шедевром времен упадка.

Все, кто за эти подлые годы голодухи, свинства, кровавого разбоя и содомии не превратился в скота и дебила, должны еще помнить грозную и прекрасную Родину, которую взяли ночью, во сне, ослепили, четвертовали, и голову ее на окровавленном блюде вынесла из шатра вероломная дева Юдифь. Преемственность власти, которую осуществляют Березовский, Чубайс и Аяцков, взращивая из пузырька угарного газа нового президента России, сулит нам преемственность бед, нескончаемых унижений и горя, под хохот Жванецкого и ужимки Хазанова, на радость «соседей-врагов».

Протухшая, как селедка, либеральная интеллигенция шамкающим ртом Вознесенского присягнула мальку. Алчная свора губернаторов, ненасытная рать президентов, изглодавшая до костей страну, присягнула дракончику».

The real agent

Murphy's Love Law

Why not? If it works?

Try a new modern approach!

I like the ambition!

From here.

There is the beginning of a shift away from treating the symptoms of diseases with synthetic drugs, towards treating the underlying cause of diseases by using one's own natural cells. Cell therapy holds the promise of prolonging and, most importantly, enhancing quality of life. This is the future of medicine and in this article I am going to look at some intriguing investment plays in the stem cell/regenerative medicine sector.

Well, basically, why not? The idea is nice! It is better to be healthy and wealthy than sick and poor!

Talk to yor dealer!

From here

Quote of the day. Kipling

IF.....

IF you can keep your head when all about you Are losing theirs and blaming it on you, If you can trust yourself when all men doubt you, But make allowance for their doubting too; If you can wait and not be tired by waiting, Or being lied about, don't deal in lies, Or being hated, don't give way to hating, And yet don't look too good, nor talk too wise: If you can dream - and not make dreams your master; If you can think - and not make thoughts your aim; If you can meet with Triumph and Disaster And treat those two impostors just the same; If you can bear to hear the truth you've spoken Twisted by knaves to make a trap for fools, Or watch the things you gave your life to, broken, And stoop and build 'em up with worn-out tools: If you can make one heap of all your winnings And risk it on one turn of pitch-and-toss, And lose, and start again at your beginnings And never breathe a word about your loss; If you can force your heart and nerve and sinew To serve your turn long after they are gone, And so hold on when there is nothing in you Except the Will which says to them: 'Hold on!' If you can talk with crowds and keep your virtue, ' Or walk with Kings - nor lose the common touch, if neither foes nor loving friends can hurt you, If all men count with you, but none too much; If you can fill the unforgiving minute With sixty seconds' worth of distance run, Yours is the Earth and everything that's in it, And - which is more - you'll be a Man, my son!

Masterpiece of the desperation. Chicken?

Mister Pu!

Shit happens...

Mr Botox regarding Rosnano.

The simplest drug ever made!

Dimethyl fumarate! Against MS and psoriasis... Nothing can be simpler! And cheaper to manufacture. Side effects? Not very common!

Erection is a critical resource. Although!

VIVUS receives positive recommendation from CHMP supporting Avanafil approval in EUVIVUS announced that the European Medicines Agency's, or EMA, Committee for Medicinal Products for Human Use, or CHMP, adopted a positive opinion recommending the granting of a marketing authorization for avanafil for the treatment of erectile dysfunction in the European Union. The CHMP recommendation will now be referred to the European Commission, which grants marketing authorization for medicines in the European Union. A final decision from the EC regarding the SPEDRA Marketing Authorization Application is expected within approximately two months.

Viscosity stops difusion. Magic.

ABC of viscosity:

More details:

Even more details:

Masterpiece of the day. 3 things...

When health is a critical resource... you have to pay double for it!

From here:

With the cost of some lifesaving cancer drugs exceeding $100,000 a year, more than 100 influential cancer specialists from around the world have taken the unusual step of banding together in hopes of persuading some leading pharmaceutical companies to bring prices down.

 

Prices for cancer drugs have been part of the debate over health care costs for several years — and recently led to a public protest from doctors at a major cancer center in New York. But the decision by so many specialists, from more than 15 countries on five continents, to join the effort is a sign that doctors, who are on the front lines of caring for patients, are now taking a more active role in resisting high prices. In this case, some of the specialists even include researchers with close ties to the pharmaceutical industry.

The doctors and researchers, who specialize in the potentially deadly blood cancer known as chronic myeloid leukemia, contend in a commentary published online by a medical journal Thursday that the prices of drugs used to treat that disease are astronomical, unsustainable and perhaps even immoral.

They suggested that charging high prices for a medicine needed to keep someone alive is profiteering, akin to jacking up the prices of essential goods after a natural disaster.

Targeted failure of the week. Post No 63 and 64. Tofacitinib and NIH's National Institute of Allergy and Infectious Diseases

Let'a start from API: the case is classical, drug is toxic and inefficient:

Pfizer Inc. (NYSE:PFE) said EMA's CHMP recommended against approval of an MAA for Xeljanz tofacitinib to treat moderate to severe rheumatoid arthritis. According to Pfizer, the committee said that while Xeljanz improved the signs and symptoms of RA and patients' physical functions, CHMP "did not believe that a consistent reduction in disease activity and structural damage had been sufficiently demonstrated." The pharma said the committee also expressed concern about serious infections, gastrointestinal perforations and malignancies in clinical trials of the oral pan-Janus kinase (JAK) inhibitor.

And then we have also very typical failure when big national institution fails:

 

NIH's National Institute of Allergy and Infectious Diseases (NIAID) discontinued the Phase IIb HVTN 505 trial to prevent HIV infection after an interim analysis showed a lack of efficacy of the vaccine regimen in the trial. An independent DSMB found that the VRC DNA/rAd5 HIV vaccine regimen -- which consists of an HIV-1 DNA plasmid vaccine injection on days 1, 28 and 56 followed by a recombinant adenovirus serotype 5 (rAd5) vector vaccine injection on day 168 -- did not prevent HIV infection nor reduce viral load in vaccine recipients who became infected with HIV. The double-blind, placebo-controlled, U.S. trial enrolled 2,504 HIV-uninfected circumcised men who have sex with men and transgender people who have sex with men. All subjects received HIV risk-reduction counseling and condoms.

NIAID said it will work to analyze the data to better understand why the vaccine regimen did not work and to guide future vaccine development efforts. The vaccine regimen was developed by NIAID's Vaccine Research Center and the trial was conducted by the HIV Vaccine Trials Network (HVTN), which is funded by NIAID.

Quote of the day. Pelevin?

Весь ум русских, «себе на уме» русских, вся их способность к многолетнему притворству, к спокойной игре среди огромного азарта, наконец, их закаленная в «рабской истории» имморальность, - все это выступило вперед и сплело чудовищный узор «провокации». «Поскобли русского и увидишь татарина», - сказал, кажется, Наполеон. Но эту мысль можно прочесть и в обратном порядке: «Возьмите монгола, жестокого и хитрого, и отточите ум его всем просвещением Запада – и вы получите русского».
Ум, душа – циничны; способности, средства – изощренны.

 

Music of the week. The art of deconstruction

Masterpiece of the human brain

Shit of the day. Who cares about geography at school?

"Я, как и простые американцы, всегда готова пойти туда, откуда пришли эти люди, и преподать им урок. И давайте не будем останавливаться на Чешской республике, пойдем во все арабские страны. Они должны узнать, что не могут безнаказанно приезжать сюда и устраивать взрывы. Давайте отправим несколько ядерных ракет в Исламабад, пусть сгорит Прага и горит в аду Тегеран. Мы должны показать им, как умеем вести дела"
 

Masterpiece of the joke. Nasdaq's reaction

Liver cancer treatment as a rocket science.

The most complicated liver cancer treatment ever developed by mankind. The video is here.

Music of the week

Shit of the day. Hollywood interpretation

Books vs TV

Health as a critical resource: the numbers

The Most Expensive Prescription Drugs in the U.S. Take a tour! Now we understand why Big Pharma gains big bucks.

Antibiotics: the american way consumption

From here.

A recent study by the Centers for Disease Control and Prevention (CDC), reported in the New England Journal of Medicine, backs this up with shocking numbers: Four out of five Americans got a prescription for an antibiotic in 2010. That amounts to 258 million courses of the drugs (keep in mind there are only about 309 million Americans total). What’s even more worrisome is that researchers estimate that half of these prescriptions weren’t even needed.

Among the drugs most commonly overprescribed were penicillin drugs, which kill bacteria by breaking down bacteria cell walls, and macrolides, a type of antibiotic that stops bacteria from growing. Azithromycin, a macrolide antibiotic frequently used to combat bronchitis, pneumonia, and sexually transmitted diseases, was the most-prescribed antibiotic.

Quote of the day

London vs Moscow

Conscience as critical resource

The video is here
http://www.youtube.com/watch?feature=player_embedded&v=lbN6qf2VVSc

Music of the week. Don't say...

Masterpiece of the day. Stalinator

Pereslegin about cold war. The masterpiece of the clear understanding how the russians were srewed up

The lecture is here: http://video.mail.ru/mail/lairlaim/_myvideo/107.html

Masterpiece.

Just more emission!

Masterpiece of the day. Stupid russians? Who knows...

ABC of bank crisis. Where to run with your money

 From here.

 

Что будет происходить

Система вынуждена и дальше продолжать сжатие иллюзорного Капитала, поскольку она более не в состоянии обеспечивать доход по нему. Поэтому дальнейшие дефолты по «надежным» долговым обязательствам некогда класса А еще впереди. Каждый подобный дефолт будет сопровождаться выборочной рекапитализацией и финансовой помощью банкам: тем институтам, дефолт которых может вызвать в финансовой системе эффект домино, будет предоставляться необходимая ликвидность. Прочие – на кладбище, и офшорные банки в первую очередь: они чистые доноры, а не потребители ресурсов финансовой системы, поэтому их падение не вызывает цепочки обрушений. Дефолт офшорных банком – личное дело их вкладчиков, а не финансовой системы.

Так что, находясь в офшорной юрисдикции, желательно знать какие иллюзорные активы предпочитает банк и интуичить состояние «здоровья» этих активов. Если не в состоянии добиться понимания, тогда оттуда лучше линять.

Куда линять

Сжатие будет продолжаться непрерывно, пока не изменится экономическая парадигма в целом. В отсутствии пространства для экспансии Капитала иного решения непрерывно воспроизводимой проблемы избыточности нет. То есть, нас ожидает ужас без конца.

Любой банк, занимающийся «инвестиционной» деятельностью, а таковых сейчас подавляющее большинство, подвержен рискам от сжатия иллюзорного Капитала. А поскольку тесновато стало сжатие будет продолжаться, то надежных банков нет по определению.

Единственным надежным активом остается золото (наличность находится под риском инфляционного сжатия). Не золотые сертификаты, по которым также легко объявить дефолт, как и по любой ценной бумаге, а именно физическое золото. Справедливости ради отметим, что как показала американская практика и над золотом висит риск его физической конфискации под страхом получить пожизненный эцих с гвоздями.

Fake?

Masterpiece of the day. Different reasons

Shit of the hipster. One day he will be punished.

Stealth probes. Stealth electrodes. Stealth research. Stealth understanding.

 

Stealth Electrodes provide direct electrical access to cell

Well, why "stealth"? It is invisible? Future goes "stealth"!

Big Pharma ethics. Fresh example

Asia’s biggest drugmaker, hid the cancer risks of its Actos drug to protect billions in sales, a jury was told in the first of more than 3,000 lawsuits over the diabetes medication to go to trial.

 

While Takeda’s internal Actos studies uncovered links to bladder cancer as early as 2004, the company didn’t alert U.S. regulators until seven years later, Michael Miller, a lawyer for plaintiff Jack Cooper, told a state court jury in Los Angeles yesterday. The company kept quiet to protect more than $1.6 billion in annual Actos sales, he added.

Targeted failure of the week. Post No 62. Phosphorodiamidate morpholino oligomer (PMO)

From here.

Sarepta Therapeutics Inc. (NASDAQ:SRPT) fell $5.25 (13%) to $33.99 on Tuesday after FDA requested additional information from the company about the existing data set for eteplirsen to "inform a decision" on whether the data could support accelerated approval for Duchenne muscular dystrophy (DMD). Sarepta said FDA made the request at a March end-of-Phase II meeting to discuss a potential NDA for the phosphorodiamidate morpholino oligomer (PMO) that induces exon 51 skipping on the dystrophin gene.

 

 Well for me (and I am professional in the pharmaceutical field) the words "the phosphorodiamidate morpholino oligomer (PMO) that induces exon 51 skipping on the dystrophin gene" sound as a unprehensible rocket science. Very often too over-complicated concepts do not work - exactly like in the present case...

Masterpiece of the day. Milk vs Coca-Cola

Shit of postmodern culture. Be free from moral!?

Music of the week. Kent

Bring, hjärtat, bring... När kärleken väntar...

Real Nanotechnology? WTF???

Masterpieces of chemical experiments in school

http://masterok.livejournal.com/tag/%D0%A5%D0%B8%D0%BC%D0%B8%D1%8F

Music of the week. USSR of the 50th

Masterpiece of russian millitary propaganda. I am scared... A little bit...

Nano-Shit: Rosnano - game over?

The video is here: http://www.youtube.com/watch?feature=player_embedded&v=KraF2CwsMxU

Masterpiece of the antirussizm. Zbyszek

China vs Germany

Be proud of being american!

Masterpiece of saying the truth

Success of a business

Gold paper to physical ratio is a stunning 100:1

If gold traders of the futures markets need any more convincing to invest in physical gold, Ned Naylor-Leyland has one- the paper to physical ratio. Simply put- the number of open positions for just 1 bar of gold.

Masterpice of the man of the mission

Not politcorrect question of the day

How a life science VC firm failed.

Very pedagogical story. Do not make the same misstakes! (The story borrowed from here.)