Thursday, August 8, 2013

Targeted failure of the week. Post No 94. Afinitor against HCC

Bild på substansens strukturformelSwiss drugmaker Novartis said on Wednesday its drug Afinitor did not show a survival benefit in patients with advanced liver cancer.

Data from a late-stage trial found that Afinitor did not extend overall survival compared with placebo in patients with locally advanced or metastatic hepatocellular carcinoma (HCC), the most common type of liver cancer.
The study was examining the efficacy and safety of Afinitor, which is also known as everolimus, in patients whose disease had progressed after treatment with or were intolerant to Onyx and Bayer's drug Nexavar.

"While we are disappointed with these results, Novartis remains committed to studying everolimus through a robust research and development program to address unmet needs in different types of cancer," said Alessandro Riva, Global Head of Oncology Development & Medical Affairs at Novartis Oncology.

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