JX-594, a targeted oncolytic poxvirus for the treatment of cancer.
Transgene S.A. (Euronext:TNG) fell EUR 1.36 (13%) to EUR 8.90 on Wednesday after it said data from 80 patients showed Pexa-Vec (JX-594) as second-line treatment missed the primary endpoint in the Phase IIb TRAVERSE trial for advanced hepatocellular carcinoma (HCC). Pexa-Vec plus best supportive care (BSC) did not improve overall survival (OS) vs. BSC alone. Transgene stopped early the open-label, international trial, which was slated to enroll about 126 patients with advanced HCC who failed Nexavar sorafenib from Bayer AG (Xetra:BAYN) and Onyx Pharmaceuticals Inc. (NASDAQ:ONXX).
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