Osmotically controlled oral drug-delivery systems have gained popularity because of the following advantages over other controlled-release strategies
- Zero-order kinetic release is achievable.
- The drug is delivered at a constant rate that is independent of time and drug concentration.
- The release rate is highly predictable.
- Higher release rates are possible compared with conventional drug-delivery systems.
- Drug release is independent of physiological factors of the gastrointestinal tract, including gastric pH and hydrodynamic conditions.
- Drug release is generally not affected by the presence of food.
- The release rate can be programmed by modulating release-control parameters.
- Delivery may be delayed or pulsed if desired.
- There is a high degree of in vivo-in vitro correlation.
- Soluble and insoluble compounds can be delivered.
- Production scale-up is easy.
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