A very
profound review on the subject. Highly recommended for those who work in
oncology field and will understand the dynamics of cancer development. One of
the conclusions:
Tumour cell phenotypes are the result of
the integration of inputs from genotype, environmental stimuli and stochastic
processes that occur within cells. Genetic and epigenetic changes that arise during
oncogenic transformation and tumour progression alter and diversify cellular
phenotypes, posing a major obstacle to the understanding and clinical
management of cancers. We suggest that the phenomenon of intra-tumour phenotypic
heterogeneity, especially aspects that are related to clonal diversity,
deserves to be recognized and accounted for during the analysis of primary
tumours, building of experimental models and design of therapeutic approaches.
Furthermore, because tumours contain
phenotypically distinct populations of both tumour and stromal cells that
interact in a dynamic and reciprocal manner, these interactions are likely to
result in the emergence of networks of interactions the properties of which can
be understood from an ecological perspective.
Yes,
personalized medicine in oncology is dead…
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