We know
that the
modern paradigm of drug development i.e. targeted approach based on key-lock
analogy (see also here)
is
not ontologically consistent. One
of the latest articles in BMJ is also worried about the situation – a lot
of resources are spent with an extremely little outcome. I think that even the majority of
practitioners of the modern paradigm understand that the current approach is
very narrow-minded, simplified and the real picture is
far more complicated.
Basically I
think that the situation is typical for the time close to paradigm shift. And
it is not surprisingly that still there are practitioners fanatically devoted
to the old (inefficient and mechanistic) paradigm. There are no any arguments
which could “open their eyes” – it should be understood. They will defend the
old dogma till the dearth – no matter what…
One of such
I think par excellence practitioner
of the modern paradigm has
described the modern approach in a very informal way. It is impossible to
take a quote from the article – the whole article is worth a thorough reading,
not less the comments of other practitioners to this post. And I follow the
blogs of a couple of such scientists with a great pleasure.
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