Patent cliff, Life ycle management and formulation strategies

Very useful article: http://www.pharmtech.com/pharmtech/Formulation/Can-Pharma-Defy-Gravity-at-the-Patent-Cliff/ArticleStandard/Article/detail/828013

 

 

 

Generic-drug competition has become increasingly aggressive, especially in an environment where healthcare policies are placing stronger emphasis on pharmacoeconomics and demanding better treatment outcomes at a lower cost. A 2012 analysis by IMS Health estimated that patent expiries will reduce brand spending in developed markets by $127 billion through 2016 (1). With drug-development expenditures escalating at an alarming rate while R&D productivity continues to decline, branded drug-makers are under pressure to maximize the value of their products throughout their lifecycles.

 

Strategies:

 

Modified-release formulations

Switch-and-grow formulations

Expand-and-grow formulations

Combination Products