Blockbusters are defined as drugs that generated $1 billion in sales in 2000, which coincides with the generally accepted beginning of the blockbuster era. That amount has been adjusted annually to reflect the CPI inflation, and it stood at $1.34 billion in 2012. (From here)
DRUG DEVELOPMENT DECONSTRUCTOR MANIFESTO: : “Tell me how you read and I'll tell you who you are.” ― Martin Heidegger
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