Astrological pharmacology… Why not?

Let’s start with definitions (I apologize for the using Wikipedia):

Pharmacology (from Greek φάρμακον, pharmakon, "poison" in classic Greek; "drug" in modern Greek; and -λογία, -logia "study of", "knowledge of") is the branch of medicine and biology concerned with the study of drug action.^[1] More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function.

The second definition:

Numerology is any study of the purported divine, mystical or other special relationship between a count or measurement and life. It has many systems and traditions and beliefs. Numerology and numerological divination by systems such as isopsephy were popular among early mathematicians, such as Pythagoras, but are no longer considered part of mathematics and are regarded as pseudomathematics by modern scientists.^[1][2]

In general it is believed that numerology is a pseudoscience. However it is widely applied in pharmacology. You are asking me in which way? As a famous Lipinski’s Rule of Five (just ask any medicinal chemist!). Wikipedia again:

Lipinski's Rule of Five is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has properties that would make it a likely orally active drug in humans. The rule was formulated by Christopher A. Lipinski in 1997, based on the observation that most medication drugs are relatively small and lipophilic molecules.^[1]

…

Lipinski's rule states that, in general, an orally active drug has no more than one violation of the following criteria:

• Not more than 5 hydrogen bond donors (nitrogen or oxygen atoms with one or more hydrogen atoms)
• Not more than 10 hydrogen bond acceptors (nitrogen or oxygen atoms)
• A molecular mass less than 500 daltons
• An octanol-water partition coefficient^[3] log P not greater than 5

I like the word “druglikeness” – the perfect description of simulation of drug development process: the development of compounds which look like drugs instead of development of original drugs. (More details here and here)

Well, do you still have any questions why the modern drug development paradigm is inefficient? Should we try an astrological approach in medicinal chemistry?