Tuesday, March 27, 2012

Antibodies are coming...

New Cholesterol-Lowering Drugs Will Test the Future Healthcare System! (Another link is here). And now the drug in question is extremely expensive antibody! Why not?  Small molecules are cheap and not sexy any more.

“We are now in a world where generic statins exist.  Over the coming months, the cost of therapy for even high doses of atorvastatin (the active ingredient of Lipitor) might be as low as $1 per day.  Antibodies, on the other hand, are expensive with the majority costing tens of thousands of dollars per year.  Insurance companies and other payers will undoubtedly look at this situation not necessarily with regard to the degree of LDL lowering provided by these compounds but rather with regard to cost.  Why reimburse the costs for a PCSK-9 antibody at $20,000 per year when a generic statin at $400 per year is almost as effective? “

Antibodies (proteins) have a lot of advantages from Big Pharma point of view:

1.       Antibodies are complicated structures and it gives an impression of high intellectual content of the medicine.

2.       Antibodies are complicated and the higher price is motivated

And who cares that the new drug is injectable and less practical compared to usual statins?

Another day, another Dirty Swan

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